Cardiac ArrhythMias Affect Millions Across the World and Are Responsible for a fifth of all deaths in the Netherlands. Currently there are multiple treatment options, ranging from life-level medicine to invasive surgical procedus. Research from Amsterdam UMC and Johns Hopkins University, Published today in the European Heart JournalSets another important step in the hunt for a one-off gene therapy that Cold Improve Heart Function and Protect Against ArrhythMias.

“ArrhythMias often Occur due to Slowing of Conduction of the Electrical Impulse through the Heart. Rapid impulse conduction is needed for the heart to beat to beat in a steady rhythm. May Experience a Life-Threatening Cardiac Arrhythmia. Cause, “Says Gerrard Boink, Cardiological at Amsterdam UMC and Coordinating Author of the Study.

The research team aimed to resolve condition slowing for the first time through the insertion of a novel gene into heart muscle cells.

“The search for a gene therapy is not a new one but until now we had the pretty fundamental problem that the potential effective genes we had identified were! Heart Muscle Cells, “Says Boink. “Think of this vector like a suitcase, up until now most of the relevant ganes was just too big to fit in,” He adds.

Researchers from the department of medical biology at amterdam umc have recently discovered A Gene (SCN10A-short, S10s), which is small enough to fit into an aav vector, the most efficient gene delivery platform for the heart.

“Finding a small enough gene was of course a crucial first step and in s10s we also have found a gene that may be able to reverse the condition slowing and allows Phil Barnett, Who Works as a Senior Researcher in the Department of Medical Biology.

The research team has shown for the first time in the current study that it is possible to introduce s10s s10s into the heart with an aav vector and that this Leads to Faster Conduction and, Thus, Thus, Thupential For the Prevention of Cardiac ArrhythMias. This has been demonstrated in Various animal models, but also in human heart muscle cells derived from stem cells and a computational model of the human heart.

“These are great early steps but now we need to continue our research in Order to find out this approach Significantly Reduce the Occurrence of ArrhythMias and Make a meaningful Impact on Patient Mortality, “Says box.

To facilitate this, box has, togeether with fellow amterdam umc cardiologist hanno tan and anesthesiologist otto kirzner, launched a spin-off company called pacing cure. The company aims to “serve as a stepping stone” to facilitate quicker clinical program.