Supercharged Ordinary Clinical Device Gets a better look at the back of the eye

Supercharged Ordinary Clinical Device Gets a better look at the back of the eye


Late Phase Indocyanine Green (ICG) Retinal Pigment Epithelial (RPE) Cell Mosaic is Visible Using BOTH BOTH BOTH Adaptive Optics (AO) and Non-AO (Convental and HIGHHHHHH MAGNIFCATION MOUNFICATION MORUMENT). Credit: Communications Medicine (2025). Doi: 10.1038/s43856-025-00803-z

Scientists at the National Institutes of Health (NIH) Have learned artificial intelligence to transform a device a device designed to see tissues in the back of the back of the eye in sharp een will share Cells. The Technique Provides Imaging Resolution that rivals the most advanced devices available and is cheaper, faster, and doesn’t require Specialized Equipment or Expertise. The strategy has implications for early detection of disease and for the monitoring of treatment response by making by making

“AI potentially puts next-generation imaging in the hands of standard eye clinics. It’s like adding a high-resolution lens to a basic camera,” called Johnny Tam, Ph.D.D.D., Investigator at Nural At Nural At Nurali Eye ‘ Institute and Senior Author of the Study Report, which was Published in Communications Medicine,

Imaging devices, knowledge as ophthalmoscopes, are widely used to examine the light-sensing retina in the back of the eye. A scanning laser ophthalmoscope is standard in eye clinics, but its resolution can only make out structures at the tissue level -things such as lesions, and the optic nervhe.







Credit: Communications Medicine (2025). Doi: 10.1038/s43856-025-00803-z

Next-Generation ophthalmoscopes enabled with adaptive optics-a technology that compensates for light distance –Can make out cell cells, providing great features, Providing Greater dagnostic information. However, adaptive optics-enabled imaging is still in the experience.

Tam and collaborators developed a custom ai system to digitally enhance images of a layer of tissue beneth the light-sensing photoreceptors, Known as the Retina’s Pigmented Epithelium (RPE). The first step was to teach the system to recognize image quality as Poor, Moderate, or Good. The researchers did this by feeding the system more than 1,400 images from different areas of the retina, obtained using adaptive-optics ophthalmoscopy.

Next, they fed the system corresponding images from the same retinal locations but obtained using standard ophthalmoscopy. An image sharpness test showed that ai improved Clarity Eightfold.

Researchers Supercare Clinical Device to get a better look at the back of the eye

Comparison of the same patoon of retina labeled with indocyanine green and visualized 3 different ways. A) Scanning laser ophthalmoscopy. B) AI-Enhanced Scanning Laser ophthalmoscopy. C) Adaptive Optics Scanning Laser Ophthalmoscopy. Arrows highlight the same cell see in different modalities. Credit: National Institutes of Health

“Our system used what it is rating from obtained from adaptive optics to digital enhance images obtained with standard ophthalmoscopy,” Said Tam. “It’s important to point that system is not creating something from noting.

These Techniques Involve Injection of a Dye Called Indocyanine Green (ICG) Into the bloodstream to Increase Contrast of Anatomical Features. In the eye clinic, ICG is usually used to image the blood vessels of the eye.

“Our ICG Imaging Strategy Allows RPE Cells to Be Quickly and Routinely Assessed in the Clinic,” said Joanne Li, Ph.D..D., First Author of the report and a Biomedical ENGINEEER In Tam ‘. “With AI, high-quality images of the rpe cells can be obtailed in a matter of seconds, using standard clinical imaging instruments.”

The RPE Cells’ Function is to Nourish and Support Photoreceptors. A variety of Blinding Conditions First Affect RPE Cells, Including Age-Related Macular Degeneration, Vitelliform Macular Dystrophy, and Stargardt Disease. However, RPE Cells cannot be easily imaged in the clinic. AI-Enhanced ICG ophthalmoscopy puts rpe imaging within reach of the typical eye clinic.

More information:
Joanne li etc., Artificial Intelligence Assisted Clinical Fluorescence imaging achieves in vivo cellular resolution Comparable to Adaptive Optics Ophathalmoscopy, Communications Medicine (2025). Doi: 10.1038/s43856-025-00803-z

Provided by National Institutes of Health


Citation: Supercharged Ordinary Clinical Device Gets a better look at the back of the eye (2025, April 23) retrieved 23 April 2025 from

This document is Subject to copyright. Apart from any Fair Dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

(Tagstotranslate) Medicine Research News (T) Medicine Research (T) Health Research News (T) Health Research (T) Health Science (T) Medicine Science

Leave a Comment

Your email address will not be published. Required fields are marked *