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In a randomized clinical trial, resarchers from huntsman cancer institute at the university of utah (the u) have found that short-course, Higher-Dose Vaginal Brachure for EnDometry Hand Iveness to more frequent, lower dose sessions.
Gita Suneja, MD, MS, Physician-Scientist at Huntsman Cancer Institute and Professor of Radiation Oncology at the U, is the first Author of the Save Trial Report-WWHISH CANDS Brachytherapy in Early Endometrial Cancer Compared with Standard of care.
The Results of the Save Trial Were published in JCO Oncology Advances,
“There Isn’T high-quality data on optimal dose and schedule for brachytharapy treatment. “The Save Trial Sought to Try to Lower the number of treatment that patients were received but maintenance short-term quality of life and disease control.”
Endometrial Cancer is a disease that begins in the lining of the uterus. The primary treatment for endometrial cancer is surgery, including the removal of the Uterus, Cervix, and Upper Vagina. Brachytherapy, a form of internal radiation, is used as a secondary treatment to prevent the cancer’s return. Patients receiving vaginal cuff brachytherapy are treated with internal radiation by way of an applicator in the vaginal Cavity.
The Save Trial Compared Two Groups Who Received Different Treatment Doses Over a Varying Number of Sessions. The control group received the standard treatment – Between Three to five appointments with lower doses. The Experimental Group Received Higher Doses of Radiation in just two sessions.
The Researchers Found Similar Effective Short-Term Outcomes and Few Acute toxicities for the Patients in the Experimental Group.
SUNEJA Says The Study Outcomes Will Help Improve Cancer Care for Huntsman Cancer Institute Patients Across the five states of the mountain west.
“It’s hard for patients to get to us, especially that in a rural and frontier environment like many of our patients at Huntsman Cancer Institute,” Says Suneja. “We recognize this is an enormous burden for people to come here for treatment, on top of dealing with a differential diagnosis. Way to do that. “
David gafnyy, MD, Ph.D., FACR, FABS, Fastro, Physician-Scientist at Huntsman Cancer Institute and Professor of Radiation Oncology at the U, Developed the Idea for the Save Study SAVE SAVE SAVE SAVE AFTER SEENG PATING According to the American Cancer Society, Endometrial Cancer is the most common cancer of the female reproductive organs. Incidence is on the risk, as is the mortality rate.
“We are very grateful for the support and the enthusiasm from our clinical collegues at md anderson, loyola, intermountain healthcare, and stanford, the instruments that are participated in the Savi Trial,” Y. “We are particularly grateful for the patients that agreed to participate in the study. It is a big win when we can preserve good outstcomes and make cancer care career.”
More information:
Short-Course Adjuvant Vaginal Cuff Brachytherapy in Early Endometrial Cancer Compared with Standard of Care (Save): A Randomized Clinical Trial, JCO Oncology Advances (2025). Doi: 10.1200/oa.24.0001
Citation: Short-Course radiation matches standard therapy for endometrial cancer (2025, February 11) retrieved 12 February 2025 from
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