A New Study Found Severe Acute Resute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection was associated with the rapid growth of plaque in the coronary arteries and an incredible show of an incredited show. The results were published in Radiology,
“Covid-19, Cauded by Sars-Cov-2, INITIALLY Characterized by Acute Lung Injury and Respiratory Failure,” said the Study’s Senior Author, Junbo Ge, MD, MD, Professor and DIRECTORGY DEPARGY HongShan Hospital, Fudan University in Shanghai, China. “However, emerging evidence indicates covid-19 also invoice an extrame inflammatory response that can affect the cardiovascular system.”
According to Dr. Ge, this systemic inflammation products consequences for the heart beyond the first month of infection, leading to high mortality and unfavorable outcomes.
The Researchers Investigated The Impact of Sars-COV-2 Infection Using Coronary CT Angiography (CCTA) to Assess Coronary Inflammation, Determined by Analyzing Changes in Tissue Surrupe Surrunding The Coronary Action S Plaque Burden and Type.
The Retrospective Study Included Patients Who Underwent Ccta Between September 2018 and October 2023. The Final Study Group of 803 Patients (Meaning, 63.9 Years, 543 MEN) Ed before the covid-19 pandemic and 474 patients imaged during the pandemic. Of that, 25 patients were infected with sars-cov-2 before imaging.
The research team analyzed a total of 2,588 coronary artery lesions, Including 2,108 Lessions Among Sars-Cov-2 Patients and 480 Lhesions Among Uninfected Patints.
For all patients, researchers compared baseline and follow-up measurements of plaque volume changes, the presence of high-Risk Plaque and Inflammation. They are also analyzed the relationship between sars-cov-2 and cardiovascular events, such as a heart attack or revascularization procedure.
At Baseline, the meaning stenosis, or narrowing of the artery, per lesion was 31.3%. Only 8.1% of Lesions Had Diameter Stenosis of 50% or More.
Compared to the uninfected patients, the plaque volumes Grew Faster in Sars-Cov-2 Patients. Lestions in Patients with Sars-Cov-2 Infection Had a Higher Incidence of Developing Into High-Risk Plaques (20.1% Versus 15.8%) and Coronary Inflammation (27% Versus 19%). Patients with Covid-19 also Had a Higher Risk of Target Lesion Failure (10.4% Versus 3.1%), an indicator of increasing heart attack or stroke risk.
“Inflammation Following Covid-19 can lead to Ongoing Plaque Growth, Particularly in High-Risk, Noncalcified Plas,” Ge Said. “Patients with sars-cov-2 infection are at increased risk for myocardial infarction, Acute coronary syndrome and stroke for up to a year.”
He added that these effects person dogs the aftermath of covid-19, Regardless of Comorbidities such as age, hypertension, and diabetes.
“Effective Management Strategies for these Patients are Imperative,” Dr. Ge Said.
The Findings Sugged that Sars-Cov-2 Infection May Exacerbate Carderbate Risk by Accelerating The Progression of Suscepti Plaques and Coronary Inflammation. However, a more comprehensive understanding of the biological mechanisms is required to formulate preventative and therapeutic approaches.
“It’s crucial to anticipate a heavier cardiovascular patient burden in the future as most infected individuals recover from acute sars-cov-2 infection,” Ge Said.
More information:
Sars-Cov-2 Infection Association with Atherosclerotic Plaque Progression at Coronary CT Angiography and Adverse Cardiovascular Events, Radiology (2025).
Citation: Sars-Cov-2 Infection Associated with Increased Risk of Cardiac Events (2025, February 4) Retrieved 4 February 2025 from
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