Credit: Tima Miroshnichenko from Pexels
Researchers have found that targeting an enzyme called pgm3 can help Stop the growth of gliooblastoma, the most dangerous type of brain tumor. Study Findings Are Published Online in the journey Science Advances,
This enzyme plays a vital role in the hexosamine synthesis path, which is involved in the processes of protein and lipid glycosylation that allows to Rapidly Grow. Lipid glycosylation is a process where Sugar Molecules Attach To Fats (Lipids) in the body.
Researchers with the ohio state University Comprehensive Cancer Center – Richar G. James and Richard J. SOLOVE Research Institute Believe That Targeting PGM3 Can Reduce Tumor Growth and Aliminal Glioblastoma cells.
“This research is important because it has found a new target called pgm3. Blocking the pgm3 enzyme can break the connection due to the connection due to the cell By Targeting this enzyme, we can develop more effective treatments for gliooblastoma, a brain tumor with very few effective treatment options, “SAIDY LeAD Author Deleiang Guo, PH.D. Director of the Center for Cancer Metabolism.
Glioblastoma is a fast-road brain that develops from glial cells in the brain. An Estimated 15,000 people each year are diagnosed with this lethal brain tumor, according to the gliooblastoma foundation.
The study highlights a promising new approach to fight gliooblastoma, giving hope for future advancements in cancer treatment, said guo, who is also the urban and shelly meyer proposest The OSUCCC – James Translational Therapeutics Program and a Professor of the Department of Radiation Oncology at the Ohio State University College of Medicine.
“Glioblastoma is the most lethal primary brain tumor, with a media survival of only 12–16 months from Diagnosis Despite Extensive Treatments,” Said Huali Su, PH.D..D. A Researcher with the Department of Radiation Oncology and Center for Cancer Metabolism at OSUCCC-James. “New molecular targets for glioblastoma are urgently needed.”
The Research Team Included Scientists from France, Along with the University of California-Los Angeles, University of California-RIRVINE and University of Louisvillle.
More information:
Huali su al, targeting pgm3 abolishes Science Advances (2025). Doi: 10.1126/sciadv.adq0334, www.science.org/doi/10.1126/sciadv.adq0334
Citation: Research Identifies Key Enzyme Target to Fight Deadly Brain Cancers (2025, April 18) Retrieved 18 April 2025 from
This document is Subject to copyright. Apart from any Fair Dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
(Tagstotranslate) Medicine Research News (T) Medicine Research (T) Health Research News (T) Health Research (T) Health Science (T) Medicine Science