Researchers at Tel Aviv University, LED by Prof. Illana gozes, examined the effects of different mutations in the adnp protein, which is essential for normal brain development and aging, on the brain cells of distinguen malees and female.

To their surprise, they found that defective protein affects completes in the two sexes: in mles, the damage occurs in a mechanism that protects, the strutin The process of neurogenesis – the production of new brain cells From stem cells – a process Crucial for Memory and Learning. In Females, on the other hand, the mechanism that regulates energy within the cell is impaired, preventing the brain from receives selfies.

All of these processes are essential for Maintigram and Learning Functions, and their disruption causes significant impairment in both sexes, leading to the development of incurable brain dishes In which adnp is also found to be defective.

The research was conducted by Prof. Ilalana Gozes, Dr. Gidon Karmon, and Doctoral Student Guy Shapira from the Faculty of Medical and Health Sciences and the Sagol School of Neuroscience at Tel Aviv University. Additional contributors to the study include prof. Noam Shomron, Dr. Gal Hacohen-Kleiman, and Doctoral Student Maram Ganaeme from the Faculty of Medical and Health Sciences, Dr. Shula Shazman from the Department of Mathematics and Computer Science at the Open University, and Researchers from the University Hospital of Thessaloniki in Greece.

The study was Published in the journey Molecular psychiatry,

Prof. Gozes stated, “The Adnp Protein was discovered in my lab, and we have been researching it for many years. e alzheimer’s disease. Additionally, it was found that Defects in the adnp gene cause adnp syndrome, a rare genetic disorder associateed with developmental delays, learning disabilities, and symptoms of autism.

“In parallel, we are developing the experiencedal drug davunetide, which is based on a fragment of the adnp protein. ‘Neurogenesis’ – The Formation of New Neurons from Stem Cells in the Adult Brain, A Process Essential For Memory and Learning.

Using Genetic Engineering, The Researchers Establed Two MODELS Reflecting different forms of adnp syndrome: mice that express only half the Normal Amount of Adnp, with only one act Ead of two, which are typical inherited from both parents, and mic With a mutation in the adnp gene that truncates the protein production process, Resulting in a Shorter-That-Normal Adnp Protein.

The Researchers Note that the most severely affected child Additionally, neurogenesis was examined in a control group of healthy mice.

To track the course of neurogenesis, a substance was injected into the mess, staining the dna of brain cells participating in the process. The data was analyzed using computational biinformatics methods, proving that adnp plays a crucial role in neurogenesis. Furthermore, A Significant Difference was found between how adnp functions in males versus females.

First, in healthy mice, neurogenesis was more active in males compared to females, while in male male mice with an adnp mutation, neurogenesis was reduced to the same level as in females. A Fundamental Difference between the sexes was also identified in an additional research method: RNA sequencing of all genes in the hippocampus of mics with the truncated adnp protein.

Prof. Gozes explained, “There was almost no overlap. The damage to the adnp protein regulate a mechanism that maintains protein Structure (Unfolded Protein Response), which regulates neurogenesis.

“In fact, the adnp gene is a master regulator of this entre mechanism in male brains, and when it is defective, the process is significantly impaired. Mitochondria -The Cell’s Energy Powerhouse –and when the mutation alters the protein’s structure, less adnp is able the mitochondria. disruptting brain function, which requires a large amount of energy. “

As part of the study, the researchers also tested the effectiveness of the experimental drug davunetde, based on the nap fragment of the adnp protein, in treatment affected mess. They observed a positive effect in all cases, with particular significant neurogenesis recovery in the model where Mice Had only half the normal adnp levels.

Prof. Gozes concluded, “Our research shows that adnp is closely linked to neurogenesis and that it functions differently in male and finding -a finding that have emerged in previous Avunetide, the drug that we discovered and are developing, is effective.

“We hope that in the future, the drug will also help Alzheimer’s Patients-In Whom We Previous Found Sex-Based Differences -S Well as well as other neurodegenative decs with is the impailed. Notable, The Rare and Incurable Disease Progressive Supranuclear Palsy (PSP), which has pathological similaries to alzheimer’s disease, showed Significal in WOMENIFIMENT IN WOMENTED SINFICTED WOMENTED Davunetide in our previous clinical study. “