Researchers at University of Tsukuba have discovered a novel mechanism involved in brain development. They found that small fragments called micronuclei produced by neuronal nuclei are released into the extracellular space during the Establishment of the Postnatal Brain. They are found

The brains of mammals, include humans, not only control neurons but also also glial cells called microglia. Microglia Modulate the Immune Response in the Central Nervous System, as Well as Various Other Functions, Including Neurogenesis, The Formation of Neural Networks, and the Control of CEROLLE OF CONTROL OF CONTROL of CEREBROVASCUR

Recent Findings have confirmed that postnatal microglia are not homogeneous cells but raather a heterogeneous population of cells that exhibit differential difference gene excursion patterns Onto in the brain. However, the detailed mechanisms by which Microglia Acquire New Functions and Change their Properties have not been educated.

In a new study Published in Nature neuroscienceDetailed observations of the Embryonic Mouse Brain Reveled that Small Nuclear Fragments Called Micronuclei are produced and released into the extrapace as neurons migrate to a process to estim the brain.

Microglia, which reside reside neurons, take up the micronuclei and use an innate immune response pathway activated by DNA Virus Infection to Alter Morphology. Furthermore, the uptake of Micronuclei Upregulates The Expression of Microglial Ganes Involved in Forming The Extracellular Matrix, The Substance that Fills The Spaces the Spaces Between Cells. Therefore, Micronuclei in the extracellular space function as mediaators that alter the properties of microglia.

Microglial subpopulations in the postnatal stage are significantly more heterogenous than there, in the adult stage and may be crucial for the functional regulation of CEREBRAL BLOOL VISSELSELS and the meninges. Further Validation of the Study Findings Would Deepen Our Understanding of the structure and function of Central Nervous System Interfaces, Such as the meninges and blood vessels.