New ‘All-Tablet’ Treatment Shows Promise for Common Form of Leukemia

New ‘All-Tablet’ Treatment Shows Promise for Common Form of Leukemia


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An International Study Published in the New England Journal of Medicine Provides hope for chronic lymphocytic leukemia (CLL) Patients with a New All-Tablet Treatment Showing Impressive Results.

The amplify clinical trial included more than 800 Never-Before-Treed Cl Patients, Across 27 Countries, and Compared a Standard Chemotherapy-Based Treatment to a New All-Tablet Approach.

Standard Chemotherapy Treatments for CLL, Plus The Immunotherapy Treatment Rituximab, Require Pateients to Undergo a lengthy infusion and can cauded immune Suppressant and Inspects.

“Our Study Indicates A New Treatment Combination of Three Targeted Therapies-Calabrutinib-Venetoclax, with or without Obinutiuzumab-Can Revious Standard Chemotherapy Treatment Regimens, “Says Professor John Seymour, Director of Hematology at Peter Maccallum Cancer Center and the Royal Melbourne Hospital.

“These results are very encouraging with the overall survival at 36 months being significantly better with this all-Tablet Combination Combination Compared to Chemotherapy treatment

“It shows the potential to achieve better outs for patients through a simple tablet-bed therapy, rather than requires to come to come to come to come to hospital and receive their treatment via an infusion.”

Prof Seymour said another all-tablet approach in CLL -USING A Different Drug Called IBRUTINIB-WAS Approved in Australia; However, this was “associateed with a concerning risk of heart complications which is frequent with the acalabrutinib-venetoclax combination.”

The trial also observed chil patients with a disease profile called “Uighv” which is generally associated with Porer Outomes Compared to Patints with the “Mutated IGHV”.

“These Patients Had Equivalent Outomes With the New Combination, Identifying this group as one that particularly benefits,” Prof Seymour Says.

“When Obinutzumab Treatment was added to the Uighv Group they Had a Progression-Free Survival Similar to the group with mutated IGHV PATINES, which is promising in this hard-to-turn cancer. BSERVE Similar Side-Effect Profiles For all the treatment with the next manageable.

“This really is wonderful news for fit, treatment naive cl patients and once this combination receives funding in Australia, we look forward to being al-offer them this safe and effector burdens of therapy in The Near Future. “

Cl is a blood cancer that affects white blood cells called lymphocytes. It is the most common leukemia in australia, with approximately 1,000 australians diagnosed each year. These study results were also presented at the American Society of Hematology Meeting in San Diego in December Last Year.

More information:
Jennifer R. Brown Et Al, Fixed-Duration Acalabrutinib Combinations in untrained Chronic Lymphocytic Leukemia, New England Journal of Medicine (2025). Doi: 10.1056/nejmoa2409804

Provided by Peter Maccallum Cancer Center


Citation: New ‘All-Tablet’ Treatment Shows Promise for Common Form of Leukemia (2025, February 6) Retrieved 6 February 2025 from

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