Following an injury, the brain tries to repair the damaged nerve fibers. Unfortunately, The Repair Process often Successeds Only Partialy, meaning many patients experience experience lasting damage to their physical and mental functions. Credit: University of Southern Denmark
A new study by resarchers at the department of molecular medicine at sdu shds light on one of the most severe consequanese of stroke: damage to the brain’s “Cables” Cables ” Manent Impairments. The study, Published in The journey of pathologywhich is based on unique tissue samples from denmark’s brain bank located at sdu, may pave the way for new treatments that help the brain repair its.
A Stroke Occurs when the Blood Supply to Part of the Brain is Blocked, Leading to Brain Damage. Following an injury, the brain tries to repair the damaged nerve fibers by re -stablishing their insulating layer, called Myelin. Unfortunately, The Repair Process often Successeds Only Partialy, meaning many patients experience experience lasting damage to their physical and mental functions.
According to Professor Kate Lykke Lambertsen, One of the Study’s Lead Author, The Brain Has The Resources to Repair Itself, “We Need to Find Ways to Hells to Hells to Hells to Hells to Ions. “
The researchers have thus focused on how inflammatory conditions hinder the rebuilding. The study has identified a particular type of cell in the brain that plays a key role in this process. These cells work to rebuild myelin, but inflammatory conditions often block their efforts.
How Researchers used the brain collection
“Using the brain collection, we can preachisely map which are the brain are most active in the repair process,” Explains Professor Lykke Lambertsen.
This mapping has enabled researchers to analyze tissue samples from denmark’s brain bank and gain a Deeper undersrstanding of the Mechanisms that control the brain’s ability to heal it.
Through Advanced Staning Techniques, Known as Immunohistochemistry, The Researchers have been able to detect Specific Cells that Play a Central Role in the Reconduction of the Reconduce of Myelin in the Damaged Arest.
The Samples were analyzed to distrust Unaffeted.
The analysis provided Insight ITO where Repair Cells Accumulate and how their activity varies defending on gender and time since the stroke.
Women and men react differently
An interesting discovery in the study is that women’s and men’s brains react differently to injuries.
“The Differences Underscore the Importance of Future Treatments Being More Targeted and Taking into account the patient’s gender and individual needs,” Says Lykke Lambertsen.
In women, it seems that inflammatory conditions can prevent cells from repairing damage, while men have a Slightly Better Ability to Initiate The Repair Process. This Difference may explain with women often experience greence greatness after a stroke.
The researchers behind the study is emphasized that the discoveries could not have been made without the danish brain bank at sdu. The collection consists of tissue samples from humans, used to understand brain diseases at a detailed level.
With access to this resource, Researchers can Investigate the Mechanisms Behind Diseases Like Stroke and Develop New Treatment Strategies.
More information:
Stefano raffaele et al, characterisation of gPR17-expressing oligodendrocyte precursors in Human Ischaemic Lesions and Correlation with Reactive Glial Responses, The journey of pathology (2024). Doi: 10.1002/path.6381
Citation: Mapping the brain’s self-healing abilitys after stroke (2025, January 24) retrieved 25 January 2025 from
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