A large study found that greater exposure to long-term air pollution was linked with increased risks for blood clots that can occur in deep veins, which, if untreated, can block blood flow and cause serious complications, even death.

These findings came from a longitudinal study that included 6,651 US adults who were followed for an average of 17 years between 2000 and 2018. Participants lived in or near one of six major metropolitan areas: New York, Baltimore, Chicago, Los Angeles, Minneapolis, and Winston-Salem, North Carolina. The findings are published in blood,

Throughout the study, 248 adults, 3.7% of the study sample, developed blood clots in deep veins that required hospital care. The likelihood of this outcome was linked to anywhere from a 39% to a more than two-fold increased risk based on long-term exposure to three different types of air pollutants.

Blood clots in deep veins, collectively known as venous thromboembolism (VTE), include deep vein thrombosis, which occurs when a blood clot forms in a deep vein of the legs, arms, or an internal organ, and pulmonary embolism, which occurs when a The blood clot breaks off from a deep vein and travels to the lungs.

Exposure to air pollution, which can set the stage for inflammation and contribute to blood clotting, has long been associated with cardiovascular and respiratory diseases. While previous research has also suggested a link to VTE, this is the largest, most comprehensive US study to report that association with three different types of air pollutants.

This included exposure to tiny air pollution particles equal to or less than 2.5 micrometers, which can be inhaled from a variety of sources, including smoke from coal-burning power plants, forest fires, and motor vehicle exhaust. Participants with greater overall exposure to this type of air pollution had a 39% increased associated risk for VTE compared to people exposed to lower levels.

People with increased exposure to oxides of nitrogen and nitrogen dioxide, pollutants most often found from vehicle exhaust, had a respective 121% to 174% increased risk.

To reach these findings, the researchers analyzed the relationship between patients hospitalized for VTE and levels of air pollution collected through extensive biweekly community-level monitoring—including samples taken from the homes of participants. They then compared those with the highest exposure levels—the top 75%—to those with the lowest exposure—the bottom 25%.

They also conducted multiple analyzes to control for variables associated with VTE, such as age, exposure to tobacco, and underlying respiratory and other health conditions.

VTE affects up to 900,000 Americans each year. Many cases occur after surgery, but other factors, including age, long periods of inactivity, heart disease, pregnancy, and genetics, can increase risks.

The research is part of the Multi-Ethnic Study of Atherosclerosis (MESA,