A new retrospective, laboratory-based observational study provides detailed Insights into the causes of fears of unknown origin in sub-sahiran Africa. Togeether with scientists from Guinea and Slovakia, Researchers from the German Center for Infection Research (Dzif) At Charité –universitsMedidizin Berlin Examined 550 Patients from Guinea Whinea Whinea WHOSI Ent Fever at the time of the Major ebola outbreak in 2014, but tested negative for the Ebola virus on site.

The goal was to use modern diagnostic methods to better understand the underlying infectious diseases. The study is Published in The journey of infectious diseases,

Fever is a Common Symptom of many diseases, including infections, cancer, and autoimmune diseases. When the cause of a person’s remain unchalar despite extended investigation, it is referred to as Fever of Unknown Origin (Fuo). Approximately Half of All Fuo Cases Worldwide Remain Undenode.

In Sub-Saharan Africa, Malaria is often suspended and treated with laboratory confirmation or further investigation. However, 90 Million Pediatric Hospitalizations Per Year in Sub-Saharan Africa Are Due to Fears not Cauded by Malaria but by Other Infections, often due to Various Due to Various Bacteria and Viruses.

A Research Team from the German Center for Infection Research (Dzif) and Charité –unversitätsmedizin Berlin, In Collaboration with Scientists from Guinea and Slovakia, Conducted A Retrospectives Hly Investigate the Pathogen Diversity of Patients from Guinea with Fever of Unknown Cause During A Major ebola outbreak in 2014.

Using serologic tests, pcr and high-throughput sequencing, at least one pathogen was detected in 275 of 550 patients. In addition to the expected malaria parasite plasmodium, Pathogenic Bacteria Such as salmonella and klebsiella strains were detected in almost one-friend of the patients.

The frequent detection of resistance to so-called first-line antibiotics in the Samples Examined and the High Rate of Co-Infections WERELSO WORRRING: 1 in 5 Infected Patients Had Multiple Infections AT the SAME TIME. Pathogens causing malaria and bacterial sepsis weree Common, Occurring Together in 12% of Adults and 12.5% ​​of Children.

Infections with highly pathogenic viruses were also common: yellow fever, lassa and ebola viruses were detected by RT-pcr in about 6% of Patients. Of particular note was the detection of infection with orungo virus, a little-known pathogen for which there are no robust assays.

Using immunofluorescence assays, The Researchers also identified igm antibodies against Several Viruses, Including Dengue, West Nile and CRIMEANGONGOTO -Negative.

“In Africa, February INKNOWN Cause Are of Treated as Malaria without further diagnosis. Cluding bacterial pathogens that cause sepsis, hemorrhagic fever viruses Including Ebola, and, as expected, Various Strains of the Malaria Parasite Plasmodium, “Explins the study the study’s last author Prof. Jan Felix Drexler.

The Findings Underscore The Urgent Need to Further Strengthen Laboratory Capacity in Sub-Saharan Africa. Early Detection of the infectious causes of fuo is Critical for Patient Care, Effective Response to OutBreaks, and Development of Regional Approved Diagnostics.

“Our results show that regionally adapted treatment Ed strengthening of regional laboratories and translational research in the sense of point-of -Care tests, “Drexler summarizes.

Provided by deutsches zentrum für in incenseforschung