A research team, affiliated with unist has unveiled soft-standing protein hydrogels that selectively deliver drugs, thereby enhancing medicinal Effects Whilel Minimizing ASSOCITEDCITY.

Professor Sebyung Kang and His Research Team from the Department of Biological Sciences at Unist Announced The Successful Creation of a Self-CrossLinkable Protein Hydrogeel. This innovative hydrogel has the potential to improve the efficacy of cancer treatment and wound healing by providing a controlled, sustained drug release without the need for harmful addives.

The research was conducted in collaboration with professor jinmyoung joo from the department of biomedical engineering and professor chaenyung cha from the department of materials Science and Engineering AT UNIST The Findings Are published in the Journal of Controlled Release,

The Unique Drug Delivery System Leverages Hydrogels, Which Allow for the Gradual Release of Drugs From Within Their Structure. This Mechanism Operates on the Principle That Drug, Encapsulated Within The Hydrogel, Is Released Progressively as the Internal Crosslinks – Formed by the Proteins -DCompese.

Significantly, the research team has developed a hydrogel that can create cross-links using proteins naturally present in the body, eliminating the need for chemical cross-linkers that often induce cytotoxicity. This Advancement Opens Up New Possibilites for Safe and Effective Drug Delivery.

To further enhance the hydrogel’s performance, proliferating cell nuclear antigen proteins was incored into the formulation to suppress immune inflammatory. In Experiences where the hydrogel was injected into mice, no immune inflammatory reactions were observed, highlighting its biocompatibility.

Testing of the hydrogel’s drug delivery capability Rowth Factors Like PDGF-BB.

Additionally, the hydrogel Proved Effective in Photothermal Chemotherapy. This Approach Involves Using Photosensitized Particles that Generate Localized HEAT when expected to light, effectively targeting and destroying cancer cells. The hydrogeel’s ability to retain these particles enhances their therapeutic effects in the tumor area.

Professor kang remarked, “The Self-Crosslinkable Protein HydroGel We Developed Serves as an Effective Platform For Delivering or Encapsulating Various Treaties Modalities “

Lead Researcher Soomin eom stated, “Our study highlights the potential for developing versatile protein hydrogels suitable for a range of biomedical applications.”