Studies by a growing number of labs have identified neurological health benefits from excursing Human Volunteers or Animal Models to Light, Sound and Or Tactille Stimulation at the brain ‘”Frequel Rhythm of 40Hz. In the latest such research at the picower institute for learning and memory and Alana Down Syndrome Center at Mit, Scientists Found that 40Hz Sensory Stimulation Improved Cognition and Recruitment Improved COGNITITY and Circuate Connectivity and Encourage The growth of new neurons in mice genetically engineered to model down syndrome.

Li-Huei Tsai, Picower Professor at Mit and Senior Author of the New Study in Plos oneSaid that the results are encouraging but also cauted that much more work is needed to test whisther the method, Called Genus (For Gamma Entrainment Using Sensory Stimulation), CLINICAL COLELD CLINICAL CONFITES FOR People with down syndrome. Her lab has been a Small Study With human volunteers at mit.

“While this work, for the first time, shows the beneficial effects of genus on down syndrome using an imperfect mouse model, we need to be cautious as there is not yet data showering whither this also Humans, “said tsai, who directs the picower institute and the Alana Center, and is a member of mit’s brain and coganitive science faculty.

Still, She Said, The Newly Published Article Adds Evidence that Genus Can Promote a Broad-Based, Restorative, “Homeostatic” Health Response in the Brain AMID A WHELGALOGIES. Most Genus Studies Have Addressed Alzheimer’s Disease in Humans or Mice, but others have found benefits from the stimulation for conditions such as “chemo brain,” and stroke,

Down syndrome benefits

In the study, the research team LED by postdoc md rezaul islam and former graduate student breaks The model recapitulates key aspects of the disorder, thought it does not exactly mirror the human condition, which is caused by carrying an extra copy of Chromosome 21.

In the first set of experiences in the paper, the team shows that an hour a day of 40Hz light and sound expert for three weeks was associateed with significant improwments Tests – TWO Involving distrolving novelty from family and one involving spatial navigation.

BeCause these kinds of memory tasks involve a brain region called the hippocampus, the resarchers looking at neural activity there and measured a significant increase in activation indicators among MCEG MICEG MICE Genus Stimulation vs. That that did not.

To better understand how stimulated mice could show improved cognition, the resultarches examined whether cells in the hippocampus changed how they express their characters. To do this, the team used a technique called single cell rna sequencing, which provided a readout of how Nearly 16,000 individual neurons and other cells transcibed their dny steo rna, Expression.

Many of the Genes with expression varied most prominently in neurons between the mice that receiving stimulation and that that that did not was directly related to forming and organizing neral circuits Synapses.

To confirm the significance of that finding, the results directly examined the hippocampus in stimulated and control mess. They found that in a critical subregion, the dentate gyrus, stimulated mice had significantly more synapses.

DIVING Deeper

The team not only examined gene expression across individual cells, but also analyzed that data to assess where there was Patterns of Coordination Multiple. Indeed, They Found Several Such “Modules” of Co-Expression. Some of this Evidence Further Substantited The Idea that 40Hz-STIMULATED MEADE MADE Important Improvements in Synaptic Connectivity, but Another Key Finding A Role for Tcf4, A Role for Tcf4, Ai Agay Aglay. of gene transcription needed for generating new neurons, or “neurogenesis.”

The team’s analysis of genetic data suggested that TCF4 is undeRexpressed in Down Syndrome Mice But The Researchers Saw Improved TCF4 Exposation in Genus-Stimulated Mice. When the resaharchers were went to the lab bench to determine where the Mice is also exhibited a differentce in neurogenesis, they found directed directed direct evidence that stimulated Mice exhibited more than the dentate Gyrus.

These increases in TCF4 Expression and Neurogenesis are only correlative, the researchrs noted, but they hypothesize that the increase in new neurons likely helps expert helps expert Synapses and Improved Short Term Memory Function.

“The increasing putative functional synapses in the dentate gyrus is likely related to the increase adult neurogenesis observed in the down syndrome Mice Following Genus Treatment,” Islam Said.

This study is the first to document

The analysis of gene expression modules also yielded other key insights. One is that a cluster of genes with expression typically declines with normal aging and in alzheimer’s disease, remained at higher expression levels amon message with 40Hz SENSORY SENSORY SENSORY SENSORY SENSORED

And the resultars Reelin-expressing neurons are especially vulnerable in alzheimer’s disease, but expression of the protein is associated with cognitive resilience amid alzheime’s disease pathology, development, TS65DN Mice Develop. About 90% of people with down syndrome development alzheimer’s disease, typical after the age of 40.

“In this study, we found that genus enhances the percentage of reln+ neurons in hippocampus of a mouse model of down syndrome, suggesing that genus may promote dognritive resilience,” ISlam SAID.

Taken Togetra with Other Studies, TSAI and Islam Said, The New Results Add Evidence that Genus Helps to Stimulate the Brain at the Cellular and Molecular Level to Mount a Molecular Level to Mount a homeostatic response to aberrations Disease Pathology, be it neurodegeenaration in alzheimer’s, demylination in chemo brain, or deficits of neurogenesis in Down Syndrome.

But the authors also cautioned that the study had limits. Not only is the ts65DN model an impecture reflection of human down syndrome, but also the mace used was all male. Moreover, the cognitive tests in the study only measured short-term memory. And finally, while the study was novel for extensive examining gene expression in the hippocampus amid genus stimulation, it did not look at changes in other critical brin Cortex.

In addition to jackson, islam and tsai, the paper’s other authors are maeesha tasnim naomi, brooke schhatz, noah tan, mitchell murdock, dong shin park, daniela rodrigues amorim, free jaang, s. S. Pineda, chinnakkaruppan adaikkan, vanesa fernandez, ute geigenmuller, rosalind mott firenze, manolis kellis and ed boyden.