It is Well Known that consuming Sugary Drinks Increases The Risk of Diabetes, but the Mechanism Behind this Relationship is Unclear. Now, in a paper appearing in Cell metabolismResearchers show that metabolites produced by gut microbes might play a role.

In a long-term cohort of us hispanic/latino adults, the results identified differenties in the gut microbiota and blood metabolites of individuals with a high into sughveragee-savedened beverages. The al aned metabolite profile seen in sugar drinkers were associated with a higher risk of developing diabetes in the subsequent 10 years. Since some of these metabolites are produced by gut microbes, this sugges that the microbiome might medium the association between sugary beverage and diabetes.

“Our study sugges a potential mechanism to explain why Sugar-Swetened Beverages are bad for your metabolism,” Says Senior Author Qibin Qi, An Epidemiologist at Albertin College of Didicine. “Although our Findings are observational, they provide insights for potential diabetes prevention or management strategies using the gut microbiome.”

Sugar-Swetened Beverages are the Main Source of Added Sugar in the diets of us adults-in 2017 and 2018, US adults consumed an average of 34.8g of added sugar each day from SUVERAGES SUCH SUCH SUCH SOCH SOCH SOCE SOCH Ice. Compared to Added Sugars in Solid Foods, Added Sugar in Beverages “Might Be More Easily Absorbed, and they have a really high energy density because they’re just sugar and water,” Says Qi. “

Previous studies in Europe and China have shown that sugar-sweetened beverages alter gut microbiome composition, but this is the first study to investigate whether this microbial change impacts host metabolism and diabetes risk. It’s also the first study to investment the issue in the us-based Hispanic/Latino Population-A Group that Experiences High Rates of Diabetes and is KNOUN to Consumes High VoLumes of So Sweetted Beeverages.

The team used data from the ongoing Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a large-scale cohort study with data from over 16,000 participants living in San Diego, Chicago, Miami, and the Bronx.

At an initial visit, participants were asked to recall their diet from the past 24 hours and had blood drawn to characterize their serum metabolites. The Researchers Collected Facal Samples and Characterized The Gut Microbiomes of a subset of the participants (n = 3,035) Take, Gut Microbiome Composition, and Serum Metabolites.

They found that high sugary beverage into intake -deefined as two or more sugary beverages per day – WAS Associated with Changes in the Abundance of Nine Species of Bacteria. Four of these species are knowledge to produce short-also fatty acids-molecules that are produced when bacteria digest fiber and that are known to positive impact glucose metabolism. In General, Bacterial Species that was positively associated with Sugary Beverage Intake Correlated with WORSE METABOLIC traits. Interestingly, these bacteria was not associated with sugar ingested from non-beverage sources.

The Researchers also found association Metabolites.

These Sugar-Aassociated Metabolites were Associated With WorsE Metabolic Traits, Including Higher Levels of Fasting Blood Glucose and Insulin, Higher Bmis and Waist-TO-Hip Ratios, and Lower Level Sity lipoprotein cholesterol (“good” cholesterol). Notably, individuals with higher levels of these metabolites had a higher likelihood of developing diabetes in the 10 years Following their Initial Visit.

“We found that Several Microbiota-Related Metabolites are associated with the risk of diabetes,” Says Qi. “In other words, these metabolites may predict future diabetes.”

Because gut microbiome samples were only collected from a subset of the participants, The Researchers Had An Insufficient Size to Determine Wheether Any Species of Gut Microbles Diabetes Risk, but this is something they plan to study further.

“In the future, we want to test wheether the bacteria and metabolites can mediate or at least partally MediaTe The Association Between Sweetned Beverages and Risk of Diabetes,” Says Qi.

The team plans to validate their findings in other populations and to extend their analysis to investigate beethr Isease.