DGIST DAPARTMENT OF NEW BIOLOGY Professor Yea KyungMoo And His Research Team Have Developed A Next-Generation Exosome-Based Drug-DELVERY Technology to Effective Treaty metabolicly Dysfunction -associated Steatohepatitis (Mash), An Incurable Metabolic Disease, in Collection With Professor Baek MON-CHANG MON-CHANG OF KYUNGPOK NHANAL UNINGPOTY SCHOOL OF MEDICINE.

The paper is Published in the journey Biomaterials,

Mash is a complex disease that ACCOMPANIES Various Metabolic Diseases, Such as Obesity and Diabetes, and Existing Therapies are limited in their effectiveness they have to get the target on Mechanism. Some Candidates Have Eather Failed Clinical Trials or Are Delayed in Approval Due to Cardiovascular Side Effects or Long-TerM Use Concerns. Such Circumstans Demonstrate the Need for Safer and More Effective Combination Treatment Strategies.

To address these challenges, Professor Yea Research Team achieved the simultaneous engineering of the interior and the surface of extractor vesicles (exosomes), exosomes, biologically deedic Vital Role in Delivering Signals Between Cells, to Formulate a Bifunctional Drug-Delivery System that is specific to the treatment of pathologically complex mash.

Exosomes, which carry various molecules including proteins, lipids, and genetic materials, are produced naturally in the bodies and are considered a promeling next-can drug-delivary system Because they have higher biocompatibility, lower toxicity, and fewer side effects than existing lipid-based drug-delivery systems (Such as covid-19 vaccines).

The research is designed to regulate metabolic abnormalities, inflammation, and fibrosis simultaneously, the main pathological mechanisms of mash, by attaching the potent fat-objectin fibroblast health Factor 21 (FGF21) to the Surface of the exosomes, and Enclosing mirna-223, which is effective for regulating inflammation and fibrosis. In Particular, the exosomes may be delivered explicitly to liver tissues, maximizing treatment efficiency.

“This research is the first to demonstrate a novel combination treatment concept Existing Treatment Strategies, “Professor Yea said. “We hope to establish a mass production system in the future that will lead to actual drug development.”