Drug that Treats Flu Shows Additional Benefit of Protecting Close Contacts from Infection

Drug that Treats Flu Shows Additional Benefit of Protecting Close Contacts from Infection


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One dose of the antiviral Baloxavir Marboxil Lowers The Chance of Transmitting The Influenza Virus to Family Members by About 30%, According to Research Published in the New England Journal of Medicine,

In the study, a phase III Global Trial of Baloxavir Marboxil (Brand Name Xofluza) LED by University of Michigan Epidemiological Epidemiological Arnold Monto, Researchers Found THE THE TECE Slowed the viral shedding that infects close contacts.

Dubbed the centers trial, the study involved 1,457 influenza-positive patients ages 5–64 and 2,681 household contacts. The patients were randomly giving eater baloxavir or a placebo, and their contacts were followed to detect influenza transmission.

“There’s always been a question: could antivirals, which are knowledge to shorten the Duration of influenza when used early in treatment, also prevent the spread of influenza,” Said Monto, A Longime Vacto, A Longteim Respiratory Contagions Advisor to the Centers for Disease Control and Prevention and the Federal Drug Administration.

“We have had drugs which treate influenza in use for many years, but it has been uniformed where No Study was designed specifically to look for a reduction in spread, or if no spread was taking place.

“Our Study was designed to directly evaluate where this meant we would finally establish that transmission could be reduced, and we were finally able to show that it was.”

Co-Author Adam Lauring, Chief of the Division of Infectious Diseases at the UM Medical School, Said the Findings Indicate Great Potential for Lowering Flu Incidence.

“This was a really exciting study to work on,” said laurying, professor of internal medicine and microbiology and immunology. “It highlights how we would potentially use an antiviral to help not just our patients but also also houses and larger communities by preventing influenza transmission. influenza outbreaks. “

BeCause other flu antivirals require a daily dose for five days and baloxavir is a single dose, it may mean great use of treatment “since it means it Protecting others, “Said Monto, Professor Emeritus of Epidemiology and Global Public Health at the um School of Public Health and Co-Director of the Michigan Center for Respiratory Virus and Responarch and Response.

“These findings extended the rationale for treatment influenza patients with the antiviral. It’s a twoofer: Shortening the Duration of the Illness of the Illness, which can also prevent complications or deatalizations While also also reduce transmission. “

Anntiviral That Reduces Viral Shedding Alaso Brings Promise for Fighting The Spread of Avian Flu, Monto Said. While it has not been studed for avian influenza eor in birds or daily cattle, researchrs have alarned from laboratory studies that Baloxavir prevents the rekinds of these kinds of influenza, ass Well.

More information:
Arnold S. Monto et al, Efficiency of Baloxavir treatment in preventing transmission of influenza, New England Journal of Medicine (2025). Doi: 10.1056/Nejmoa2413156

Provided by University of Michigan


Citation: Drug That Treats Flu Shows Additional Benefit of Protecting Close Contacts from Infection (2025, April 24) Retrieved 24 April 2025 from

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