MPSAs reveal IUPAC motifs for the 5’ss specificities of risdiplam and branaplam. A, B Structures of (A) risdiplam and (B) branaplam. C MPSA performed in the context of a minigene library spanning exons 6, 7, and 8 of SMN2, In this library, the 5’ss of exon 20 was replaced by 285 variant 5’ss sequences of …
Graphical abstract. Credit: Device (2024). DOI: 10.1016/j.device.2024.100292 An endoscopic mapping device, developed over the course of a decade by scientists at the Auckland Bioengineering Institute, consists of an inflatable sphere covered in sensors, delivered down the esophagus and able to measure electrical activity in the gut. In the same way, abnormal heart electrical signals can …
Novel device for stomach complaints is successful in human trial Read More »
Credit: Pixabay/CC0 Public Domain Research in animals has shown that the diabetes drug dulaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist may reduce symptoms of depression. A new study published in Brain and Behavior reveals the mechanisms that are likely involved. By conducting a range of tests in mice treated with and without dulaglutide, …
Credit: Marius Mann from Pexels From the outside, Seoul’s main hospitals seem unchanged: ambulances pull up, patients walk in, staff in white coats walk around purposefully. But for weeks, South Korean health care has been struggling. Surgeries have been cancelled, crucial chemotherapy sessions delayed, and it is nearly impossible to get a walk-in appointment since …
Quit medicine for farming? South Korean doctors speak out Read More »
Credit: Pixabay/CC0 Public Domain Despite progress toward cleaner air in the US, a new study suggests that communities of color across the nation are shouldering a growing burden of diseases linked to air pollution. A paper published today by researchers at the George Washington University suggests that racial and ethnic disparities in cases of pollutant-linked …
Credit: Unsplash/CC0 Public Domain Sports coaches could strengthen athletes’ mental health and protect them from mental illness by adopting an “authentic leadership” style, a new study reveals. Researchers found when athletes perceived that their coach engaged in behaviors such as openly sharing information, showing understanding of their strengths and weaknesses, acting in an ethical manner, …
Coaches can boost athletes’ mental health by being ‘authentic leaders’ Read More »
Credit: Unsplash/CC0 Public Domain Every additional step up to around 10,000 steps per day reduces the risk of death and cardiovascular disease (CVD), regardless of how much remaining time is spent sedentary, reports a large population-based study published online in the British Journal of Sports Medicine, Some previous studies have shown that greater daily step …
Credit: CC0 Public Domain Even people whose physical activity levels fall short of recommended guidelines, but who manage to do some during their leisure time, are likely to have a lower risk of stroke than their sedentary peers, suggests a pooled data analysis of the available evidence, published online in the Journal of Neurology, Neurosurgery …
Data show even low levels of leisure time physical activity help to lower stroke risk Read More »
Credit: CC0 Public Domain Every year, more than one million deaths occur globally because of exposure to short-term (hours to days) fine particulate matter (PM2.5) in air pollution, according to a new report, with Eastern Asia reporting more than 50% of deaths attributable to short-term PM2.5 globally. To date most studies have focused on the …
Credit: CC0 Public Domain Living in leafy areas near gardens, parks, and green spaces, may boost bone density and lower the risk of osteoporosis, finds research published online in the Annals of the Rheumatic Diseases, Lower levels of air pollution in green spaces is a significant contributory factor to the associations found, conclude the researchers. …
Living in ‘leafy’ areas may boost bone density and lower osteoporosis risk, finds study Read More »