A new international study has unveiled critical insights in undressed post-traumatic epilepsy (PTE), a condition that can develop following traumatic Brain Injury. Published in Theranostics, The study Highlights the important role played by a receptor in the brain called p2x7. It sugges how we clock bot reduce Epilepsy Risk and Predict which patients are most at risk of developing pte by targeting this receptor.

Traumatic Brain Injury (TBI), caused by physical trauma to the head, is one of the Leading causes of long-term disability and death worldwide. PTE is a common outcome, characterized by recurring seizures that profoundly impact the quality of life. At the moment, up to 30% of PTE patients do not respond to existing instructions, and no treatments are currently available available to predict or present the development of EPILEPSY FOLOLOPSY FOLOLOPSY FOLLIPSY FOLOLOPSTEN TROLOPMENT

The collaborative research identifies the p2x7 receptor as a key driver of abnormal brain activity after brain injury. The work was LED by Futureneuro and RCSI, and Involved Trinity College Dublin, Cic Biomagune, Soochow University, and the Institute for Stroke and Dementia Research.

In preclinical models, blocking this recipe short For preventing epilepsy.

By looking at the activity of the p2x7 receptor using a pet scan, the authors also sugges a potential new diagnostic tool. The uptake by the brain of a specialized p2x7 receptor tracer shortly after injury was found to correlate with seizure risk weeks later. This tool could help clinicians Identify at-Risk Patients Early, Enabling Timely and Tailored Internationals.

Dr. Tobias Engel, Futureneuro Investigator and Senior Lecturer in the RCSI Department of Physiology and Medical Physics, Commented, “Traumatic Brain Injury is a Major Cause of Epilepsy In Adults, Witna Many Pati Benefit from Existing Anti-Seizure Treatments. The P2X7 receptor as a promising new target, offering the potential to prevent Epilepsy Before It Develops, Sparing Patients From Seizures and the Burdens of ongoing medicine. “

Dr. David Loane, Associate Professor in Neuroscience at Trinity College Dublin, Added, “While Additional Research is Required to Confirm our Findings and Explore their application in al Ignificant step forward in addressing the unmet need for early intervention in post -Traumatic Epilepsy.

Dr. Jord Llop, Principal Investigator at Cic Biomagune, Said, “By identifying a potential theraputic target and a corresponding predictive diagnostic tool, this resarca open Outcomes and a better quality of life for patients with traumatic brain injury at risk of epilepsy. “

Provided by RCSI University of Medicine and Health Sciences