Mount Sinai Researchers have developed a method to uncover the hidden immune cells that harbor the Human immunodeficiency virus (HIV), A Discovery That Brings Medical Experts One Step Closer to Au For the infection affecting Nearly 40 Million People Globally. The findings were Published in Nature Communications,

HIV is a virus that Attacks cells in the body fighting off infections, thus weaqening the immune system. Antretroviral Therapies can treat the HIV infection by Halting the spread of the virus and protecting the immune system, but do not cure the virus. Mount sinai researchers have developed a method to geneetically mark immune cells that carry hiv, an important milestone that grown potentially lead to approaches that eliminate Cells and cure the virus.

The team created a novel cell lineage-tracing model to reveal where the virus hides, and developed genetic profiles of t cells, or white blood cells that are crucial to immune response and reetain eite Inactive HIV. The researchers said their genetic analysis of the dormant HIV-Infected Cells Provides a New Gene Pathway for Potential Treatment.

“The main obstacle to cure the infection is that the virus hides in immune cells that are related to Identtify and study. If we can identify the cells infected with How to eliminate them, “said corresponding author benjamin k. Chen, MD, Ph.D., Professor of Medicine (Infectious Diseases), Microbiology, Microbiology, Pharmacological Sciences, And IMMUNLOGY and IMMUNOLOGY and Immunotherapy at the ICHN school of medicine at mount sinai.

The researchers developed a genetic system to mark hiv-infected cells and then study bot infected and dormant cell population. They used humanized Mice Models to Develop a Fluorescent Red-to -Green Switch triggered by the HIV infection that persists even if the virus is Dormant. This Switch Results in the Permanent Marking of HIV-Infected Cells in Mice and Enables Lineage Lineage of the HIV infection.

The research team profiled more than 47,000 t cells including acutely infected, treated, and uninfected cells, to then Identtify Hellper T Cells (Whoch Detect Infections), Memory Cells, Nequel Cells, Nequel Cells, Nequel Cells Fight off infections), proliferating cells, regulatory t cells, and subsets within these larger groups. Through their analysis, they predicted and identified nine distinct types of t cells that have been inactive hiv cells. Their Investigation also identified Persistent T Cells With HIV Even after 10 and 29 days of antytroviral therapies.

The Findings Sugged New Therapies that target the reservoir of Dormant Hiv-Infected Cells as a Potential Cure for the Virus. The mount sinai team will next study and test specific approaches to reactivate Dormant HIV and Determine if it is possible to reduce to reduce the reservoir of infected cells.