A New Rat Study Exploes Lung Function and Placental Changes in the presence of infection and inflammation. The study sugges treating the mother with steroids before giving birth may improve both lung and placental function, potenally preventing a Kammon Lung Disorder Associated with Prematurity.

The findings of This first-off-IF-Kind Study Are published in the American Journal of Physiology-Lung Cellular and Molecular Physiology,

Ten Percent of Babies Worldwide Are Born Prematurely. One of the most common conditions preemies Experience is impaired lung development, which often leads to a condition called Bronchopulmonary Dysplasia (BPD).

BPD Causes Breathing Difability and the need for supplemental oxygen, which also carries health risks. BPD can be caused by a variety of factors, including a type of inflammatory infection in the mother’s uterus called chorioamnionitis. The more severe the mother’s infection, the more severe bpd tends to be.

A standard of care for pregnant mothers is to administer steroids before the baby is born to help improvement Lung Function. But the impact of these steroid treatments on the placenta has not been well-defined.

Abnormal function of the placenta in a pregnancy affected by chorioamnionitis may also negatively affected affected In this new study, resarchers analyzed the effects of prenatal steroid treates on the placenta tissue as well as infant rats’ lung tissue and pulmonary function tweet

A group of pregnant rats were treated with the steroid betrathasone two days before giving birth. The Research Team Examined Placental Structure At Birth and Lung Function in the infants when they were two weeks old. Compared to animals that was not treated for infection and a control group without the associate inflammation, the treated group:

• Showed restored lung structure.
• Increased Pulmonary vessel density.
• Normalized spiral artery formation in the placementa. Spiral Arteries Deliver Blood (And Nutrients) from mother to child.
• Showed alternation of Multiple Placental Genes, Including Decreased Inflammatory Signaling and An Increase in Placental Prolactin, A Hormone Involved in MainTainy Pregnancy. Prolactin is a particular interesting target for future Studies BECAuse Its Role in Lung Development or Lung Injury has not yet characterized.

“These findings sugged that antenatal steroids improvental function, preserve lung growth, and prevent (right ventricular hypertrophy) in infant rats, suggesting a potential began Researchers Wrote.