Second-Hand Smoke Exposure during Childhood Leaves Its Mark on Children’s DNA

Second-Hand Smoke Exposure during Childhood Leaves Its Mark on Children’s DNA


Graphical abstract. Credit: Environment International (2024). Doi: 10.1016/j.envint.2024.109204

Children exposed to Second-Hand Smoke at home are more like to show certain changes in the epigenome, which can alter the way genes are expressed. These epigenetic changes could influence the development of diseases in the future.

This is the main conclusion of a study by the barcelona institute for Global Health (Isglobal). The results, Published in Environment InternationalHighlight the need to Reduce Exposure to Second-Hand Smoke, Especially in Children’s environments.

Our DNA acts as an instrument manual for the body. Without changing the contents of the “book” (Ie the gene sequence), tobacco smoke can add “marks” to certain pages, affecting the way these instruments are read. One of these marks, dna methylation, is one of the main epigenetic mechanisms, allowing gene expression to be turned on or off.

Second-Hand Smoke’s Mark on the DNA

While the effects of Maternal Smoking during pregnancy have long been Known to affect the epigenome, this research is among the first to show how many how second-hand-hands smoke experts are foundhood may also

The Study Included Data From 2,695 Children from European Countries: Spain, France, Greece, Lithuania, Norway, The Netherlands, The Neetherlands, The UK and Sweden. The participants were aged 7–10 years and were volunteers from Six cohorts of the pregnancy and childhood epigenetics consortium (pace).

Using Blood Samples from Participants, The Team Looked at the Level of Methylation at Specific DNA Sites Along The Genome and Related It to the number of smokers in the Househld (0, 1, 1, Or 2 Or more).

DNA Methylation Changes were identified in 11 regions (called cpgs) Most of these regions Had also been linked in Previous Studies to Direct Exposure to Tobacco in Active Smokers or DURING PREGNANCY. In addition, Six of them are associateed with diseases for which smoking is a risk factor, such as as asthma or cancer.

“Our Study Shows that Second-Hand Smoke During Childhood Leaves Its Mark at the Molecular Level and Can Alter The Expression of Ganes that Influence Disease Disease Disease Disease Disease Disease Disease that Influence Disease is Susceptithood,” Isglobal Researcher and First Author of the Study.

A global problem with long-term consequences

Despite Increasing Regulation of Smoking in Public Places, The Household Remines a Major Source of Second-Hand Smoke Exposure For Children. In 2004, it was estimated that 40% of children worldwide was expected to tobacco smoke. Childhood Exposure to this pollutant not only increases the risk of Respiratory and Cardiovascular Disease, but can also affect neurological development and immune function.

“The Results Sugged that Second-Hand Smoke in Childhood Leads to Epigenetic Changes Similar ENSIVE MEASURESURES to Reduce Childhood Exposure to Tobacco Smoke, Both at home and indoors, “Says Mariona Bustamante, Isglobal Researcher and Senior Author of the Study.

“It is not a question of appearance to the individual responsibilities of Families: Exposure to Tobacco is a Public Health Problem and Hides an issue of social inquality. Ether with the Influence of Powerful Commercial Interests, Make it Difique To reduce expenses to second-hand smoke in certain households, “Concludes cosin-tomàs.

More information:
Marta Cosin-Tomas Et Al, Association of Exposure to Second-Hand Smoke during Childhood with Blood DNA METHYLTION, Environment International (2024). Doi: 10.1016/j.envint.2024.109204

Provided by Barcelona Institute for Global Health


Citation: Second-Hand Smoke Exposure during Childhood Leaves Its Mark On Children’s DNA (2025, February 11) retrieved 11 February 2025 from

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