A research team at the institut de neurociències of the universitat autònoma de barcelona (incine) has developed a new protein capable of improving memory and review Disease. The new compound – Hebe, Generated by Fusing Three Proteins – Represts a new approach in the search for new strategies to tackle the disease.

Until now, therapies focused on a single protein have had limited success, due to the complexity of the biological processes involved in aging and neurodegeenaration. Now, The Research Groups Genepy for Diseases Affecting The CNS, Gene Therapy Strategies for Neurometabolic Diseases, Systems Pharmacology and Bioinformatics Ombined their area of ​​Expertise to work togeether in the investment of therapeutic alternatives.

The result has been the development of hebe, a chimeric protein made up of three proteins: s-klotho (s-kl), strem2 and timp2, which in previous stodies have been found to have Ffects of the disease.

The Research Team Carried Out The Binding of the three proteins using computer simulations, and subsequent, confirmed their stability and efficacy in tests in chells and in muurine models of alzheimer ‘. Their research is Published in the journey Biomedicine & Pharmacotherapy,

The results demonstrate that mice treated with the chimeric protein show an improvement in memory and a reduction in the legs of the tau protein, one of the main indicators of the disease. The study has also observed a reduction, although not significant, in the levels of beta-aamyloid, the other protein that is also implicated.

“Hebe represents a step forward in the development of new the therapeutic strategies against Alzheimer’s Disease,” EXPLAINS JON ESANDI, Inc-Oab Researcher and First Author of the Study.

“The results we present show the potential of hebe and pave the way for its passible application in the clinic,” Says miguel chillón, coordinator of the research.