When blood cancer cells break through the bone and multiply, Tumor Cells within Dangerly Diverse and the Immune Response in the Region Changes, Report Researchers from Berlin and Heidelberg in Science immunologyThe detailed Insights Into Cancer Progression could Advance Diagnostics and Treatment.

The incurable bone marrow cancer multiple myeloma often development in the bone marrow over decades. In advanced stages, lesions form that can destroy the bone and spread to other parts of the body.

An interdisciplinary team from the berlin institute of health at charité (bih), the max delbrück center, the Queen Maryn Mary University of London’s Precision HEALTHCAREN HEALTHCARENCARICARE Center at Heidelberg University Hospital (Ukhd), The University of Heidelberg And the German Cancer Research Center (DKFZ), Together with Other National and International Partners, Has Been Investigating What Haappens in these Lestions when myeloma cells first too wrong first too.

The Researchers Discovered that Tumor Cells Diversified Drastically when Exiting The Bone Marrow, which also affects the immune cells in the cancer lesions. The new Findings Blad Contribute to more Precise Diagnostics and Therapy.

When the tumor cells leave the bone, they find themselves in a completely different environment with different environmental conditions.

“We suspect that this diversity helps the cancer cells adapt to survival outside the bone, enabling them to spores to other areas of the body,” Says Dr. Niels Weinhold, Head of Translational Myloma Research at the Ukhd’s Department of Hematology, Oncology and Rheumatology.

Using Innovative Single-Cell and Spatial Omics Technologies, The TEAM also examined for the first time how the immune system reacts to this breakway of cancer cells from the bone. They discovered significant changes in the type and number of immune cells in the microenvironment of the cancerous Lessions. For example, certain immune cells, Know as t cells, Had very different receptors and surface molecules in the foci outside the bone – a posesible adaptation to the newly emergeed heterogended heterogended heterogetey

Uncovering the interaction between the immune system and cancer

“There seems to be a co-evolution between tumor and immune cells, in which both sides react to changes in the other,” Says Professor Simon Haas, Co-CO-CORRERRER DAPONDING AUTHOR OF THE STUDY. Heads a lab in the joint focus area “Single-cael approaches for personalized medicine” at the bih, max delbrück center, and charité-universitätsmedizin beerlin. He is also Chair for Single Cell Technologies and Precision Medicine at Phuri.

The Researchers Hypothesize that this intensified interaction between the immune system and the cancer may bot promote and hinder the fight against the disease. The team is currently investigating which factors contribute positively or negatively to this interaction.

For their analyses, the International Team Used Tissue Samples that Originated from Myloma Lestions in Various Parts of the Body. The material was obtained eite by image-guided biopsies or during operations on fracture-prone or alredy broken bones.

“Single-cael analysis and spatial multi -omics technologies enabled us to simultaneously investigate a wide range of properties of thoughts of individual cells, Taking into CCNTO CCICHINT ACCONTE POTSUT s Dr. Llorenç solé boldo, one of the first authors of the study.

The results could influence the diagnosis and therapy of myeloma in the future. Currently, Samples for Diagnosis are usually taken from the Iliac Crest (Part of the Pelvis) of Patients. However, Since the study has shown that cancer and immune cells in hotspots where the cancer cells break out of bone Differ significantly from in the Iliac Crest, these sites may be beetter suiter suiter And allow a more priority assessment of the disease and Possible Adjustment of Therapy.