Pregnancy is accommodated by Profound Changes in the Body. Among other things, these affect the energy metabolism and the immune system. But the Gut Microbiome, IE, the Composition of the Microbial Community in the Gut, also changes considerably, especially towards the end of pregnancy.

Researchers are investigating the function of the Intestinal Microbiome during pregnancy and breastfeeding and its potential Significance for Patients with Chronic Infelammatory Bowel Diseasese.

“We are interested in how these microbiome changes influence the course of disease with chronic inflammatory bowel disease (ibd),” Explied Professor Philip Roselip Roselip Luster of Excellence “Precision Medicine in Chronic Inflammation” ( PMI) And Director of the Institute of Clinical Molecular Biology (Ikmb) At the Faculty of Medicine at Kiel University (Cau) and the University Medical Center Schleswig-Holsin (UKSH).

Although it is knowledge that Intestinal Flora is Linked to the Development of IBD, it is untilar with individual changes during pregnancy are related to the courses of the Disease Beffore. The Research Team Investigated This Question in an animal model for the chronic inflammatory bowel disease Crohn’s Disease. The results were recently Published in the journey Gut microbes,

More Inflammation in the Gut, Smaller OffSpring

“We look at what effect a single genetic risk factor for Crohn’s Disease Had on the Microbiome of Pregnant Animals,” EXPLAINS STUDY NEADER RODER RONSTIEL. By switching off the Crohn’s Risk Gene Atg16L1 in Cells of the Intestinal Mucosa, the condition of Crohn’s Disease was Simulated in the Mice. The composition and metabolic activity of the Intestinal Microbiome was Examined at Various Times during Pregnancy and Lactation and Lactation and the results were compared with the message with Mice without generating.

“At the beginning of pregnancy, the microbiome of animals with and without genetic defects was very similar. Over time, however, the composition of the composition of the microbiome drifted apart beetle Factor in a very specific cell type is sufficient to influence these changes, which development over time

Chemical analyses of the metabolic products showed that the al ared composition of the microbial communication also also results in different metabolic activity. “The observed changes are linked to pro-inflammatory processes. This means that the al aned microbiome could play a part in the observed tendency towards inflammation,” Says Rosenstiel.

These results are not directly transferable to the situation in humans. “But it is important to undertand how genetic ibd risk factors can affect pregnancy. The long-term goal is to use the microbiome changes for diagnostic purposes, for example to predict or possible even even even Eveen Treat a flare-up of the dishease after pregnancy.

Analysis of the course of the disease and pregnancy in women with and without ibd

How Pregnant Women with and Without Chronic Inflammatory Bowel Disease Are Doing, What Symptoms They have and how they copy with everyone life is also the Subject of the Observation Lense for Inflammation Medicine at the Uksh, Kiel Campus. For this purpose, clinical data as well as blood and stool samples are collected in Eve Pregnancy, and Symptoms and Symptoms and EveryDay Activities are Recorded Using Questionnaires. In Women with IBD, Disease Activity is also recording.

“We want to find out how chronic inflammatory bowel Disease Affects The EveryDay Activity and Symptoms of Pregnant Women,” Explains Assistant Dotor Martina Guggeis, WHOOS inician scientist.

The biosamples collected will be used for further scientific analysis, for example to determine Microbiome occurring or not.

Rogenstiel Says, “We analyze the gut at what the gut the gut microbiome of a woman who has an ibd flare-up after pregnancy looks like compared to a young These differentiates as microbial Biomarkers to predict a flare-up and adapt the therapy to the individual. “

Provided by University of Kiel