These composite brain images from the study of WTC Responders Reveal Evidence of Amyloidosis. Areas shaded in red and yellow indicate regions of the brain with amyloid. Credit: Stony Brook University
Closing in on 25 Years Since the World Trade Center (WTC) Attacks, WTC Responders Continue to Suffer long-term effects from their experts at ground zero. One Issue of Possible Growing Concern is Signs of Early Dementia in Responders. The results of a new brain imaging study by resichers at stony brook medicine indicates a link Between WTC Exposure Duration and the presence of amyloid in the brain.
Amyloid is a protein in the body that can form abnormal deposits in tissues and organs. These deposits can build up, cause a condition called amyloidosis, and are associated with numerous diseases, one of which is alzheimer’s dishease. Many alzheimer’s patients have high levels of amyloid in areas of the brain.
This study, Published in the Journal of Alzheimer’s DiseaseIncludes scans of the cerebrum of 35 WTC Responders (26 Men and Nine Women), with an average age of 56 years.
“The take home point with this study is that we saw from the imaging that Duration of WTC Exposures Had a Direct Link to Amyloid in the Brain, Specifically in the OLFACTORY CORTEEX,” Says SEAS SEAS SEAS SEAS SEAS Professor In the department of family, population and preventant medicine in the renaissance school of medicine (rsom), and in the program of Public Health at Stony Brook University.
Clouston stressed the study showed that WTC Responders who were expected for a lengthy period of time and who did not wear masks as at ground zero Had notable evidence of amyloid in the brain.
“It is also important to emphasize that presence of amyloid was associateed with cognitive impairment in this cohort,” Adds bethor, the edmund d. Pelrigrino Professor in the rsom and director of the stony brook wtc Health and Wellness Program. Nearly Half of the Subjects (17) Showed Cognitive Impairment Based on a Standard Battery of Tests.
Both Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) Scans was called on the Volunteer Patients Over Three Years. These patients are monitored for their health at the stony brook wtc program.
WTC Exposures Included Several Inhaled Exposures to Fine Particulate Matter and Air Pollutants Such as Polycyclic Aromatic Hydrocarbons and Dioxins.
The Research Team Found That Responders Expeded to these elements via their works for months for Additionally, when comparing non-masked to masked responders, the brain imaging also showed that high levels of amyloid in the olfactory cortex were associated with more amyloid Throughout the brain.
The Author Write that “Amyloidosis is Concern ogy in severely and chronically exposed individuals. Efforts to remediati workplace expenses and protect workers might reduce the long-term burden of dementia in the population. “
Clouston and colleagues point out that amyloidosis in this population may not cause alzheimer’s, thought the association between cerebral amyloidosis and these conditions is strong. They hope to advance the research with larger patients and additional brain scans over time.
More information:
Minos kritikos et al, Exposure Duration and Cerebral Amyloidosis in the OLFACTORY CORLD of World Trade Center Responders: A Positron Emission Tomography and Magnetic Resonance Resonance Imaging Study, Journal of Alzheimer’s Disease (2024). Doi: 10.1177/13872877241302350
Citation: Study provides evidence of amyloidosis in the brains of some world trade Center Responders (2025, January 24) retrieved 24 January 2025 from retrieved 24 January 2025 from
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