A new study in Heart Rhythm has examined the potential dangers of consuming energy drinks for patients with genetic heart diseases. A cohort of 144 sudden cardiac arrest survivors was examined at Mayo Clinic, of which seven patients (5%) had consumed one or more energy drinks in close proximity to their cardiac event. While the study did not prove direct causation, caution is advised, and doctors recommend that patients consume energy drinks in moderation.

Lead investigator of the study, Michael J. Ackerman, MD, Ph.D., Genetic Cardiologist at Mayo Clinic and Director of the Mayo Clinic Windland Smith Rice Sudden Death Genomics Laboratory in Rochester, MN, says, “The energy drink market in the United States has been growing consistently over the past few years, raising concerns about the potential combined effects of caffeine consumption and additional unregulated ingredients in these beverages. Energy drinks are not regulated by the US Food and Drug Administration (FDA), so researching the effects that these drinks have on our patients is of utmost importance.”

Energy drinks contain caffeine ranging from 80 mg to 300 mg per serving, compared with 100 mg in an 8-ounce cup of brewed coffee. However, most of these energy drinks contain other stimulating ingredients in addition to caffeine that are unregulated by the FDA, such as taurine and guarana. It has been postulated that the highly stimulating and unregulated ingredients alter heart rate, blood pressure, cardiac contractility, and cardiac repolarization in a potentially pro-arrhythmic manner.

Ehud Chorin, MD, Ph.D., Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, co-author of the accompanying editorial commentary “Arrhythmogenic Foods—An Underestimated Medical Problem?” says, “Establishing a probable cause of an arrhythmia includes inquiring about a potential exposure to toxins or medications.

“An increasing number of substances in the standard diet are found to have unwanted cardiac effects, prompting the consideration of a novel subcategory in a patient’s clinical history intake: arrhythmogenic foods. Energy drinks fall in this category. The findings reported in this study should be viewed in the context of the large body of evidence suggesting arrhythmogenic effects of certain foods, especially when consumed in large quantities or large concentration by high-risk patients.”

In addition to examining the consumption of energy drinks among the cohort of sudden cardiac arrest survivors, the researchers also looked closely at the type of cardiac event as well as the conditions surrounding the event, such as exercise and other stressors known to be associated with genetic heart disease-associated cardiac arrhythmias.

Dr. Ackerman explains, “While there seemed to be a temporal relationship between energy drink consumption and the seven patients’ sudden cardiac arrest event, a myriad of potential ‘agitators’ that could have also contributed to a genetic heart disease-associated arrhythmia occurred, like sleep deprivation, dehydration, dieting or extreme fasting, concomitant use of QT-prolonging drugs, or the postpartum period. As such, unusual consumption of energy drinks most likely combined with other variables to create a ‘perfect storm’ of risk factors, leading to sudden cardiac arrest in these patients.”