A recent study carried out by a research team from the paul-ehrlich-infestutut investigated the immunomodulating properties of β-governments. These are natural sugar compounds found in Bacteria, Fungi and Grains. The results indicate that β-GLUCANS can target the immune system and modulate pro-inflammatory responses. Their potential to suppress allergic reactions and offer new approaches to allergy treatment is particularly promising. The research was Published in the International Journal of Molecular Sciences,

β-glucans’ potential as an adjuvant is particularly promising. One use for adjuvants is as a vaccine ingredient to strengthen the immune response and thus strengthen vaccination protection.

Adjuvants are also used for therapeutic allergens, which assist in influencing (modulating) The immune system in a way that contributes to reduction the allergic reactions and to helping the allergen.

Allergen-Specific Immunotherapy Involves Resuvants in Order to Modulate Allergen-Specific (Known as Th2) Immune Reactions in a Targeted Manner and to Re-Setabrip .

A research group Led by pd Dr. Stefan Schülke, Head of the Research Allergology Division at the Paul-Ehrlich-Institut Conducted A Study to Test Six Different β-Glucans, Including Zymosan and its Varll respectives , 3 glucans for their influence on the immune System.

The group found that these substances activate different immune cells and influence the release of certain pro-inflammatory substances in different ways. Zymosan and β-1,3 glucan in Particular was able to reduce the production of inflammatory markers in the expers and showed a promising ability to supports allergy-reviews.

The results of the study are promising and could help to develop new the therapeutic approaches for the treatment of allergies. In the future, β-Glucans could play an important role in preventing allergic reactions and controlling the immune response in a targeted manner.

Highlighted results in detail

The study analyzed bot immunological (receptor activation, cytokine second, t-call modulation) and metabolic parameters (metabolic state) in dendritic cells-specific immune Mice. It was found that all of the β-glucans tested activated the C-Type lectin receptor (CLR) Dectin-1, while the “toll” -Like Receptor 2 (TLR2) was particularly triggered by zymsan. The β-GLUCANS also LED to different degrees of cytokine second and activation of cell metabolism in the dendritic cells.

A more detailed study of the β-glucans zymosan, β-1,3 glucan and β-1,3 /6 glucan showed CD80 , CD86 and mhcii to varying degrees. Another Finding: The Cytokine Secretion Induced by β-Glucans was partly dependent on the activation of the activation of the intracellular dectin-1 Adapter Molecule Syk.

In co-computations of dendritic cells with mouse t cells sensitized to the Major birch pollen allergen bet v 1, four of the β-glucans tested suppressed allergen-imstouted il-5 Secretion. However, only zymosan and β-1,3 glucan significantly reduced the second of interferon gamma (ifnγ). This sugges that β-glucans tested have different impacts on the ability of dendritic cells to target t cells for allergens.

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